Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome.

نویسندگان

  • Jacqueline C Escobar Piccoli
  • Maria Gabriela Valle Gottlieb
  • Luciano Castro
  • Luiz Carlos Bodanese
  • Euler Roberto Fernandes Manenti
  • Mauricio Reis Bogo
  • Alessandra Peres
  • Maria Izabel U M da Rocha
  • Ivana Beatrice Mânica da Cruz
چکیده

Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.

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عنوان ژورنال:
  • Arquivos brasileiros de endocrinologia e metabologia

دوره 52 8  شماره 

صفحات  -

تاریخ انتشار 2008